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Monomethyl auristatin E intermediate-8

CAT: 0804-HY-78901ASize: 1 EachDry Ice: NoHazardous: No
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Description
Monomethyl auristatin E intermediate-8 is an intermediate reagent in the synthesis of Monomethyl auristatin E. Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs).
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/monomethyl-auristatin-e-intermediate-8.html
Solubility
10 mM in DMSO
Smiles
CC(CC)C([C@@H](CC(OC(C)(C)C)=O)O)NC(OCC1=CC=CC=C1)=O
Molecular Formula
C20H31NO5
Molecular Weight
365.46
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75 (7) :1376-87.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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