Monomethyl auristatin E intermediate-3

CAT:

804-HY-43146-03

Size:

50 mg

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UNSPSC Description: Monomethyl auristatin E intermediate-3 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].
Target Antigen: Others
Type: Reference compound
Related Pathways: Others
Applications: Cancer-programmed cell death
Field of Research: cancer
Assay Protocol: https://www.medchemexpress.com/monomethyl-auristatin-e-intermediate-3.html
Purity: 97.26
Solubility: 10 mM in DMSO
Smiles: CCC(C)C(C(O)=O)NC(OCC1=CC=CC=C1)=O
Molecular Weight: 265.30
References & Citations: [1]Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87.
Shipping Conditions: Room Temperature
Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
Clinical Information: No Development Reported

Cat	Name
HY-43146-02	Monomethyl auristatin E intermediate-3
HY-43146-03	Monomethyl auristatin E intermediate-3
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