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Monomethyl auristatin E intermediate-9

CAT: 0804-HY-78903-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-78903-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Monomethyl auristatin E intermediate-9 is an intermediate reagent in the synthesis of Monomethyl auristatin E. Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs).
CAS Number
120205-58-5
UNSPSC
12352005
Hazard Statement
H301
Target
Drug Intermediate; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/monomethyl-auristatin-e-intermediate-9.html
Purity
98.75
Solubility
10 mM in DMSO
Smiles
CC[C@H](C)[C@@H]([C@@H](CC(OC(C)(C)C)=O)OC)N(C(OCC1=CC=CC=C1)=O)C
Molecular Formula
C22H35NO5
Molecular Weight
393.52
Precautions
P264-P270-P330-P405-P501
References & Citations
[1]Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75 (7) :1376-87.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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