Monomethyl auristatin E intermediate-9

Monomethyl auristatin E intermediate-9

• CAS Number: 120205-58-5
• UNSPSC Description: Monomethyl auristatin E intermediate-9 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].
• Target Antigen: Others
• Type: Reference compound
• Related Pathways: Others
• Applications: Cancer-programmed cell death
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/monomethyl-auristatin-e-intermediate-9.html
• Purity: 98.75
• Solubility: 10 mM in DMSO
• Smiles: CC[C@H](C)[C@@H]([C@@H](CC(OC(C)(C)C)=O)OC)N(C(OCC1=CC=CC=C1)=O)C
• Molecular Weight: 393.52
• References & Citations: [1]Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported