Monomethyl auristatin E intermediate-4

• UNSPSC Description:

  Monomethyl auristatin E intermediate-4 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].

• Target Antigen:

  Others

• Type:

  Reference compound

• Related Pathways:

  Others

• Applications:

  Cancer-programmed cell death

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/monomethyl-auristatin-e-intermediate-4.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCC(C)C(NC(OCC1=CC=CC=C1)=O)C(CC(OC(C)(C)C)=O)=O

• Molecular Weight:

  363.45

• References & Citations:

  [1]Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1823777-46-3