Products for Research Use Only
RegisterLogin

Monomethyl auristatin E intermediate-4

CAT: 0804-HY-43147Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-43147Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Monomethyl auristatin E intermediate-4 is an intermediate reagent in the synthesis of Monomethyl auristatin E. Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs).
CAS Number
1823777-46-3
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/monomethyl-auristatin-e-intermediate-4.html
Solubility
10 mM in DMSO
Smiles
CCC(C)C(NC(OCC1=CC=CC=C1)=O)C(CC(OC(C)(C)C)=O)=O
Molecular Formula
C20H29NO5
Molecular Weight
363.45
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75 (7) :1376-87.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-79196-01Monomethyl auristatin E intermediate-15
HY-78899Monomethyl auristatin E intermediate-6
HY-78903-01Monomethyl auristatin E intermediate-9
HY-78910Monomethyl auristatin E intermediate-12
HY-78901AMonomethyl auristatin E intermediate-8
HY-78913-01Monomethyl auristatin E intermediate-14
HY-79205Monomethyl auristatin E intermediate-17
HY-33048-01Monomethyl auristatin E intermediate-1
HY-78908-01Monomethyl auristatin E intermediate-11
HY-43146-01Monomethyl auristatin E intermediate-3

Alternative Products

CatalogName
OR1005449Monomethyl auristatin E intermediate-14
OR1036620Monomethyl auristatin E intermediate-9
OR1036317-01Monomethyl auristatin E intermediate-1
T208361-01Monomethyl auristatin E intermediate-8
OR1032361-01Monomethyl auristatin E intermediate-7
OR1005081Monomethyl auristatin E intermediate-11
OR1031759Monomethyl auristatin E intermediate-3
OR1006028Monomethyl auristatin E intermediate-2
GTR19261400-01Monomethyl auristatin E intermediate-10
T208363-01Monomethyl auristatin E intermediate-17

Popular Products