Monomethyl auristatin E intermediate-17

CAT:

804-HY-79205

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CAS Number: 2382378-57-4
UNSPSC Description: Monomethyl auristatin E intermediate-17 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].
Target Antigen: Others
Type: Reference compound
Related Pathways: Others
Applications: Cancer-programmed cell death
Field of Research: cancer
Assay Protocol: https://www.medchemexpress.com/monomethyl-auristatin-e-intermediate-17.html
Solubility: 10 mM in DMSO
Smiles: O=S(O[C@@H]([C@@]1([H])N(CCC1)C(OC(C)(C)C)=O)[C@@H](C)C(OCC2=CC=CC=C2)=O)(C3=CC=C(C=C3)C)=O
Molecular Weight: 517.63
References & Citations: [1]Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87.
Shipping Conditions: Room temperature
Clinical Information: No Development Reported

Cat	Name
HY-79205	Monomethyl auristatin E intermediate-17
HY-79196-02	Monomethyl auristatin E intermediate-15
HY-79196-01	Monomethyl auristatin E intermediate-15
HY-78913-02	Monomethyl auristatin E intermediate-14
HY-78908-03	Monomethyl auristatin E intermediate-11
HY-78901-02	Monomethyl auristatin E intermediate-7
HY-78901-01	Monomethyl auristatin E intermediate-7
HY-43146-02	Monomethyl auristatin E intermediate-3
HY-33048-05	Monomethyl auristatin E intermediate-1
HY-78903	Monomethyl auristatin E intermediate-9