Ibuprofen-13C6

CAT: 0804-HY-78131S3Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-78131S3Size:1 mg
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Description
Ibuprofen-13C6 ((±) -Ibuprofen-13C6) is a 13C labeled Ibuprofen (HY-78131) . Ibuprofen ((±) -Ibuprofen) is a potent, orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen ((±) -Ibuprofen) can be used in the research of pain, swelling, inflammation, infection, immunology, cancers[1][2][3][4][5].
CAS Number
[1216459-54-9]
Product Name Alternative
(±) -Ibuprofen-13C6
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; COX; Isotope-Labeled Compounds; Parasite
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ibuprofen-13c6.html
Purity
98.24
Solubility
10 mM in DMSO
Smiles
OC(C([13C]1=[13CH][13CH]=[13C]([13CH]=[13CH]1)CC(C)C)C)=O
Molecular Formula
C7 13C6H18O2
Molecular Weight
212.24
Precautions
H302
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-246.|[2]Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61 (1) :2-7.|[3]Hassan Akrami, et al. Inhibitory effect of ibuprofen on tumor survival and angiogenesis in gastric cancer cell. Tumour Biol. 2015 May;36 (5) :3237-43.|[4]Sharon M Rymut, et al. Ibuprofen regulation of microtubule dynamics in cystic fibrosis epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311 (2) :L317-27.|[5]Emmanuelle Bignon, et al. Ibuprofen and ketoprofen potentiate UVA-induced cell death by a photosensitization process. Sci Rep. 2017 Aug 21;7 (1) :8885.|[6]Nathan D Pennock, et al. Ibuprofen supports macrophage differentiation, T cell recruitment, and tumor suppression in a model of postpartum breast cancer. J Immunother Cancer. 2018 Oct 1;6 (1) :98.|[7]Thomas Krøigård, et al. Protective effect of ibuprofen in a rat model of chronic oxaliplatin-induced peripheral neuropathy. Exp Brain Res. 2019 Oct;237 (10) :2645-2651.|[8]Sarah Ilkhanipour Rooney, et al. Ibuprofen Differentially Affects Supraspinatus Muscle and Tendon Adaptations to Exercise in a Rat Model. Am J Sports Med. 2016 Sep;44 (9) :2237-45.|[9]M W Konstan, et al. Ibuprofen attenuates the inflammatory response to Pseudomonas aeruginosa in a rat model of chronic pulmonary infection. Implications for antiinflammatory therapy in cystic fibrosis. Am Rev Respir Dis. 1990 Jan;141 (1) :186-92.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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