Ibuprofen (sodium)

Ibuprofen ((±) -Ibuprofen) sodium is an orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen sodium inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen sodium is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen sodium can be used in the research of pain, swelling, inflammation, infection, immunology, cancers[1][2][5][8].

31121-93-4

(±) -Ibuprofen (sodium)

12352005

H302, H319, H335

Apoptosis; COX; Parasite

Reference compound

Anti-infection; Apoptosis; Immunology/Inflammation

COVID-19-immunoregulation

Cancer; Infection; Inflammation/Immunology; Neurological Disease

https://www.medchemexpress.com/ibuprofen-sodium.html

10mM

99.98

DMSO : 20.83 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : ≥ 100 mg/mL

O=C(O[Na])C(C)C1=CC=C(CC(C)C)C=C1

C13H17NaO2

228.26

H302, H319, H335

[1]Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61 (1) :2-7. |[2]Hassan Akrami, et al. Inhibitory effect of ibuprofen on tumor survival and angiogenesis in gastric cancer cell. Tumour Biol. 2015 May;36 (5) :3237-43. |[3]Sharon M Rymut, et al. Ibuprofen regulation of microtubule dynamics in cystic fibrosis epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311 (2) :L317-27. |[4]Emmanuelle Bignon, et al. Ibuprofen and ketoprofen potentiate UVA-induced cell death by a photosensitization process. Sci Rep. 2017 Aug 21;7 (1) :8885. |[5]Nathan D Pennock, et al. Ibuprofen supports macrophage differentiation, T cell recruitment, and tumor suppression in a model of postpartum breast cancer. J Immunother Cancer. 2018 Oct 1;6 (1) :98. |[6]Thomas Krøigård, et al. Protective effect of ibuprofen in a rat model of chronic oxaliplatin-induced peripheral neuropathy. Exp Brain Res. 2019 Oct;237 (10) :2645-2651. |[7]Sarah Ilkhanipour Rooney, et al. Ibuprofen Differentially Affects Supraspinatus Muscle and Tendon Adaptations to Exercise in a Rat Model. Am J Sports Med. 2016 Sep;44 (9) :2237-45. |[8]M W Konstan, et al. Ibuprofen attenuates the inflammatory response to Pseudomonas aeruginosa in a rat model of chronic pulmonary infection. Implications for antiinflammatory therapy in cystic fibrosis. Am Rev Respir Dis. 1990 Jan;141 (1) :186-92.

Room Temperature

4°C (Powder, sealed storage, away from moisture)

Reference compound1

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