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Ibuprofen-d4

CAT: 0804-HY-78131S2-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-78131S2-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ibuprofen-d4 is a deuterium labeled Ibuprofen. Ibuprofen is a potent, orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen ((±) -Ibuprofen) can be used in the research of pain, swelling, inflammation, infection, immunology, cancers[1][2][3][4][5].
UNSPSC
12352005
Target
Apoptosis; COX; Isotope-Labeled Compounds; Parasite
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; Others
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Inflammation/Immunology; Neurological Disease
Purity
99.28
Solubility
10 mM in DMSO|DMSO : 100mg/mL (ultrasonic) |H2O : 1mg/mL (ultrasonic)
Smiles
OC(C([2H])(C1=CC=C(CC(C)C)C=C1)C([2H])([2H])[2H])=O
Molecular Formula
C13H14D4O2
Molecular Weight
210.31
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61 (1) :2-7.|[3]Hassan Akrami, et al. Inhibitory effect of ibuprofen on tumor survival and angiogenesis in gastric cancer cell. Tumour Biol. 2015 May36 (5) :3237-43.|[4]Nathan D Pennock, et al. Ibuprofen supports macrophage differentiation, T cell recruitment, and tumor suppression in a model of postpartum breast cancer. J Immunother Cancer. 2018 Oct 16 (1) :98.|[5]M W Konstan, et al. Ibuprofen attenuates the inflammatory response to Pseudomonas aeruginosa in a rat model of chronic pulmonary infection. Implications for antiinflammatory therapy in cystic fibrosis. Am Rev Respir Dis. 1990 Jan141 (1) :186-92.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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