Ibuprofen-13C, d3

• Description :

  Ibuprofen-13C, d3 is the 13C- and deuterium labeled Ibuprofen. Ibuprofen is an anti-inflammatory agent targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively[1].

• Product Name Alternative :

  (±) -Ibuprofen-13C, d3

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Apoptosis; COX; Isotope-Labeled Compounds; Parasite

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Anti-infection; Apoptosis; Immunology/Inflammation; Others

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Cancer

• Solubility :

  10 mM in DMSO

• Smiles :

  OC(C(C1=CC=C(C=C1)CC(C)C)[13C]([2H])([2H])[2H])=O

• Molecular Formula :

  C12 13CH15D3O2

• Molecular Weight :

  210.29

• Precautions :

  P264-P270-P330-P501

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-223.|[2]Driban JB, et al. Joint inflammation and early degeneration induced by high-force reaching are attenuated by ibuprofen in an animal model of work-related musculoskeletal disorder. J Biomed Biotechnol. 2011;2011:691412|[3]Khwaja F, et al. Ibuprofen inhibits survival of bladder cancer cells by induced expression of the p75NTR tumor suppressor protein. Cancer Res. 2004 Sep 1;64 (17) :6207-13.|[4]Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61 (1) :2-7.|[5]Palayoor ST, et al. Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen. Oncogene. 1999 Dec 2;18 (51) :7389-94.|[6]Rao GH, et al. Ibuprofen protects platelet cyclooxygenase from irreversible inhibition by aspirin. Arteriosclerosis. 1983 Jul-Aug;3 (4) :383-8.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [1261394-40-4]