(R)-(-)-Ibuprofen

(R)-(-)-Ibuprofen

• CAS Number: 51146-57-7
• UNSPSC Description: (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects.
• Target Antigen: NF-κB
• Type: Reference compound
• Related Pathways: NF-κB
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology; Cancer
• Assay Protocol: https://www.medchemexpress.com/_R_-_-_-Ibuprofen.html
• Purity: 99.96
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: C[C@H](C1=CC=C(CC(C)C)C=C1)C(O)=O
• Molecular Weight: 206.28
• References & Citations: [1]Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14.|[2]Scheuren N, et al. Modulation of transcription factor NF-kappaB by enantiomers of the nonsteroidal drug ibuprofen. Br J Pharmacol. 1998 Feb;123(4):645-52.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Launched