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(R) - (-) -Ibuprofen

CAT: 0804-HY-78131B-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-78131B-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(R) - (-) -Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R) - (-) -Ibuprofen exhibits anti-inflammatory and antinociceptive effects.
CAS Number
51146-57-7
Product Name Alternative
(R) -Ibuprofen
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
NF-κB
Type
Reference compound
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/_R_-_-_-Ibuprofen.html
Purity
99.96
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@H](C1=CC=C(CC(C)C)C=C1)C(O)=O
Molecular Formula
C13H18O2
Molecular Weight
206.28
Precautions
H302, H315, H319, H335
References & Citations
[1]Evans AM, et al. Comparative pharmacology of S (+) -ibuprofen and (RS) -ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14.|[2]Scheuren N, et al. Modulation of transcription factor NF-kappaB by enantiomers of the nonsteroidal drug ibuprofen. Br J Pharmacol. 1998 Feb;123 (4) :645-52.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
NF-κB

Chemical Information

Ibuprofen, (-)-

Levibuprofen is an ibuprofen. It is an enantiomer of a dexibuprofen.

CAS Number51146-57-7
PubChem CID114864
IUPAC Name(2R)-2-[4-(2-methylpropyl)phenyl]propanoic acid
Molecular FormulaC13H18O2
Molecular Weight206.28
XLogP3.5
Topological Polar Surface Area37.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Heavy Atom Count15
Formal Charge0
Complexity203
SMILES
C[C@H](C1=CC=C(C=C1)CC(C)C)C(=O)O
InChI
InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)/t10-/m1/s1
InChIKey
HEFNNWSXXWATRW-SNVBAGLBSA-N
Chemical Structure
2D Structure
2D structure of Ibuprofen, (-)-
CAS: 51146-57-7
CID: 114864
Formula: C13H18O2
MW: 206.28
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight206.28
XLogP33.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Exact Mass206.130679813
Monoisotopic Mass206.130679813
Topological Polar Surface Area37.3 Ų
Heavy Atom Count15
Formal Charge0
Complexity203
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
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