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Lapatinib (tosylate)

CAT: 0804-HY-50898CSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-50898CSize:1 Each
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Description
Lapatinib (GW572016) tosylate is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively[1].
CAS Number
1187538-35-7
Product Name Alternative
GW572016 (tosylate) ; GW2016 (tosylate)
UNSPSC
12352005
Hazard Statement
H302-H312-H332
Target
Autophagy; EGFR; Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lapatinib-tosylate.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=C(C)C=C1)(O)=O.O=S(CCNCC2=CC=C(C3=CC=C4C(C(NC5=CC(Cl)=C(C=C5)OCC6=CC(F)=CC=C6)=NC=N4)=C3)O2)(C)=O
Molecular Formula
C36H34ClFN4O7S2
Molecular Weight
753.26
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
References & Citations
[1]Rusnak DW, et al. The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol Cancer Ther. 2001 Dec;1 (2) :85-94
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
EGFR/ErbB1/HER1; ErbB2/HER2

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