Lapatinib (Standard)

• Description :

  Lapatinib (Standard) is the analytical standard of Lapatinib. This product is intended for research and analytical applications. Lapatinib (GW572016) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively[1].

• Product Name Alternative :

  GW572016 (Standard) ; GW2016 (Standard)

• UNSPSC :

  12352005

• Target :

  Autophagy; EGFR; Ferroptosis; Reference Standards

• Type :

  Reference Standards

• Related Pathways :

  Apoptosis; Autophagy; JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/lapatinib-standard.html

• Smiles :

  O=S(CCNCC1=CC=C(C2=CC=C3C(C(NC4=CC(Cl)=C(C=C4)OCC5=CC(F)=CC=C5)=NC=N3)=C2)O1)(C)=O

• Molecular Formula :

  C29H26ClFN4O4S

• Molecular Weight :

  581.06

• References & Citations :

  [1]Rusnak DW, et al. The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol Cancer Ther. 2001 Dec;1 (2) :85-94

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards

• CAS Number :

  [231277-92-2]