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Lapatinib (ditosylate) (Standard)

CAT: 0804-HY-50898AR-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-50898AR-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lapatinib (ditosylate) (Standard) is the analytical standard of Lapatinib (ditosylate) . This product is intended for research and analytical applications. Lapatinib ditosylate (GW572016 ditosylate) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively[1].
CAS Number
388082-77-7
UNSPSC
12352100
Target
Autophagy; EGFR; Ferroptosis; Reference Standards
Related Pathways
Apoptosis; Autophagy; JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=S(CCNCC1=CC=C(C2=CC=C3C(C(NC4=CC(Cl)=C(C=C4)OCC5=CC(F)=CC=C5)=NC=N3)=C2)O1)(C)=O.O=S(C6=CC=C(C)C=C6)(O)=O.O=S(C7=CC=C(C)C=C7)(O)=O
Molecular Formula
C43H42ClFN4O10S3
Molecular Weight
925.46
References & Citations
[1]Rusnak DW, et al. The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol Cancer Ther. 2001 Dec;1 (2) :85-94
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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