Lapatinib-d4

CAT: 0804-HY-50898S-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-50898S-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lapatinib-d4 is the deuterium labeled Lapatinib (HY-50898) . Lapatinib is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively[1][2].
CAS Number
[1184263-99-7]
Product Name Alternative
GW572016-d4; GW2016-d4
UNSPSC
12352005
Target
Autophagy; EGFR; Ferroptosis
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Autophagy; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
99.02
Solubility
10 mM in DMSO|DMSO : 125mg/mL (ultrasonic)
Smiles
CS(C([2H])([2H])C([2H])([2H])NCC1=CC=C(O1)C2=CC(C(NC3=CC(Cl)=C(C=C3)OCC4=CC(F)=CC=C4)=NC=N5)=C5C=C2)(=O)=O
Molecular Formula
C29H22D4ClFN4O4S
Molecular Weight
585.08
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Rusnak DW, et al. The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol Cancer Ther. 2001 Dec;1 (2) :85-94.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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