DBCO-acid (GMP)

• Description :

  DBCO-acid GMP is a GMP grade DBCO-acid (HY-42972) . DBCO-acid is a click chemistry reagent used in the synthesis of ADC linker DBCO-NHS ester ((HY-115524) and (HY-115545) ), and agent-linker conjugates DBCO-PEG-MMAE (HY-111012 and HY-126690) . DBCO-acid contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups[1][2][3][4].

• CAS Number :

  [1353016-70-2]

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  Biochemical Assay Reagents

• Type :

  GMP Small Molecules

• Related Pathways :

  Others

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/dbco-acid-gmp.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(CCC(O)=O)N(C1)C2=C(C=CC=C2)C#CC3=C1C=CC=C3

• Molecular Formula :

  C19H15NO3

• Molecular Weight :

  305.33

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501

• References & Citations :

  [1]Zimmerman ES, et al. Production of site-specific antibody-drug conjugates using optimized non-natural amino acids in a cell-free expression system. Bioconjug Chem. 2014 Feb 19;25 (2) :351-61.|[2]Klein PM, et al. Click-Shielded and Targeted Lipopolyplexes. Methods Mol Biol. 2019;2036:141-164. |[3]Wang M, et al. Transforms of Cell Surface Glycoproteins Charge Influences Tumor Cell Metastasis via Atypically Inhibiting Epithelial-Mesenchymal Transition Including Matrix Metalloproteinases and Cell Junctions. Bioconjug Chem. 2023 Aug 16;34 (8) :1498-1507. |[4]Klein PM, et al. Folate receptor-directed orthogonal click-functionalization of siRNA lipopolyplexes for tumor cell killing in vivo. Biomaterials. 2018 Sep;178:630-642.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  GMP Small Molecules

• Clinical Information :

  No Development Reported