DBCO-acid (GMP)

DBCO-acid (GMP)

• CAS Number: 1353016-70-2
• UNSPSC Description: DBCO-acid GMP is a GMP grade DBCO-acid (HY-42972). DBCO-acid is a cleavable ADC linker used in the synthesis of ADC linker DBCO-NHS ester (HY-115524 and HY-115545), and agent-linker conjugates DBCO-PEG-MMAE (HY-111012 and HY-126690)[1]. DBCO-acid is a click chemistry reagent, itcontains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
• Target Antigen: ADC Linker
• Type: GMP Small Molecules
• Related Pathways: Antibody-drug Conjugate/ADC Related
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/dbco-acid-gmp.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(CCC(O)=O)N(C1)C2=C(C=CC=C2)C#CC3=C1C=CC=C3
• Molecular Weight: 305.33
• References & Citations: [1]Zimmerman ES, et al. Production of site-specific antibody-drug conjugates using optimized non-natural amino acids in a cell-free expression system. Bioconjug Chem. 2014 Feb 19;25(2):351-61.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported