DBCO-acid

CAT: 0804-HY-42972-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0804-HY-42972-01Size:10 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
DBCO-acid is a click chemistry reagent used in the synthesis of ADC linker DBCO-NHS ester ((HY-115524) and (HY-115545) ), and agent-linker conjugates DBCO-PEG-MMAE (HY-111012 and HY-126690) . DBCO-acid contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups[1][2][3][4].
CAS Number
[1353016-70-2]
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
Biochemical Assay Reagents
Type
ADC Related
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dbco-acid.html
Purity
99.71
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(CCC(O)=O)N(C1)C2=C(C=CC=C2)C#CC3=C1C=CC=C3
Molecular Formula
C19H15NO3
Molecular Weight
305.33
Precautions
H302, H315, H319, H335
References & Citations
[1]Zimmerman ES, et al. Production of site-specific antibody-drug conjugates using optimized non-natural amino acids in a cell-free expression system. Bioconjug Chem. 2014 Feb 19;25 (2) :351-61.|[2]Klein PM, et al. Click-Shielded and Targeted Lipopolyplexes. Methods Mol Biol. 2019;2036:141-164.|[3]Wang M, et al. Transforms of Cell Surface Glycoproteins Charge Influences Tumor Cell Metastasis via Atypically Inhibiting Epithelial-Mesenchymal Transition Including Matrix Metalloproteinases and Cell Junctions. Bioconjug Chem. 2023 Aug 16;34 (8) :1498-1507. |[4]Klein PM, et al. Folate receptor-directed orthogonal click-functionalization of siRNA lipopolyplexes for tumor cell killing in vivo. Biomaterials. 2018 Sep;178:630-642.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported

Related Products

CatalogName
HY-140269DBCO-PEG12-acid
HY-120903-01DBCO-C3-Acid
HY-140267-01DBCO-PEG5-acid
HY-140268DBCO-PEG8-acid
HY-120678-01DBCO-PEG4-acid
HY-151820-01DBCO-PEG24-acid
HY-42974-01DBCO-PEG3-acid
HY-121805-01DBCO-​C6-​acid
HY-140266-01DBCO-PEG2-acid
HY-140265-01DBCO-PEG1-acid

Alternative Products

CatalogName
MBS5768937DBCO-acid
MBS3600763-01DBCO acid 2
M11435-01DBCO acid 1
JH917390DBCO-PEG2-acid
JH917393DBCO-PEG1-acid
JH917403DBCO-PEG4-Acid
BIPG2543-01DBCO-PEG8-acid
BA2575-1000DBCO-C3-Acid
BA2469-1000DBCO-C6-acid
MF-0148125-01DBCO-PEG3-acid

Popular Products