DBCO-acid

• Description:

  DBCO-acid is a click chemistry reagent used in the synthesis of ADC linker DBCO-NHS ester ((HY-115524) and (HY-115545) ), and agent-linker conjugates DBCO-PEG-MMAE (HY-111012 and HY-126690) . DBCO-acid contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups[1][2][3][4].

• UNSPSC:

  12352203

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Biochemical Assay Reagents

• Type:

  ADC Related

• Related Pathways:

  Others

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/dbco-acid.html

• Purity:

  99.71

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(CCC(O)=O)N(C1)C2=C(C=CC=C2)C#CC3=C1C=CC=C3

• Molecular Formula:

  C19H15NO3

• Molecular Weight:

  305.33

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Zimmerman ES, et al. Production of site-specific antibody-drug conjugates using optimized non-natural amino acids in a cell-free expression system. Bioconjug Chem. 2014 Feb 19;25 (2) :351-61.|[2]Klein PM, et al. Click-Shielded and Targeted Lipopolyplexes. Methods Mol Biol. 2019;2036:141-164.|[3]Wang M, et al. Transforms of Cell Surface Glycoproteins Charge Influences Tumor Cell Metastasis via Atypically Inhibiting Epithelial-Mesenchymal Transition Including Matrix Metalloproteinases and Cell Junctions. Bioconjug Chem. 2023 Aug 16;34 (8) :1498-1507. |[4]Klein PM, et al. Folate receptor-directed orthogonal click-functionalization of siRNA lipopolyplexes for tumor cell killing in vivo. Biomaterials. 2018 Sep;178:630-642.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen)

• Scientific Category:

  ADC Related

• Clinical Information:

  No Development Reported

• CAS Number:

  [1353016-70-2]