DBCO-amine (GMP)

DBCO-amine (GMP)

• CAS Number: 1255942-06-3
• UNSPSC Description: DBCO-amine GMP is a GMP grade DBCO-amine (HY-W000423). DBCO-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. DBCO-amine is a click chemistry reagent, itcontains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
• Target Antigen: ADC Linker
• Type: GMP Small Molecules
• Related Pathways: Antibody-drug Conjugate/ADC Related
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/dbco-amine-gmp.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCN
• Molecular Weight: 276.33
• References & Citations: [1]Ermira Pazolli, et al. Splicing modulator antibody-drug conjugates and methods of use. WO2019232449A1.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported