BWA-6047

• Target:

  Androgen Receptor|||PROTACs|||Molecular Glues

• Related Pathways:

  Endocrinology/Hormones|||PROTAC

• Bioactivity:

  BWA-6047 is a dual AR/AR-V7 and GSPT1 PROTAC-type degrader (AR: DC50= 3.7 nM; AR-V7: DC50= 3.0 nM; GSPT1: DC50= 1.2 nM) . It facilitates the ubiquitination and degradation of AR/AR-V7 and, through molecular glue properties, induces a PPI between GSPT1 and CRBN, leading to GSPT1 degradation. BWA-6047 is applicable in prostate cancer research.

• Molecular Formula:

  C42H46ClN5O7

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C