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BWA-6047

CAT: 0931-T207136-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T207136-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
Androgen Receptor, PROTACs, Molecular Glues
Related Pathways
Endocrinology/Hormones, PROTAC
Bioactivity
BWA-6047 is a dual AR/AR-V7 and GSPT1 PROTAC-type degrader (AR: DC50= 3.7 nM; AR-V7: DC50= 3.0 nM; GSPT1: DC50= 1.2 nM) . It facilitates the ubiquitination and degradation of AR/AR-V7 and, through molecular glue properties, induces a PPI between GSPT1 and CRBN, leading to GSPT1 degradation. BWA-6047 is applicable in prostate cancer research.
Molecular Formula
C42H46ClN5O7
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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