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BML-265

CAT: 0804-HY-169948Size: 1 EachDry Ice: NoHazardous: No
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Description
BML-265 is a potent EGFR tyrosine kinase inhibitor. BML-265 disrupts Golgi integrity and abolishes secretory protein transport of diverse cargos. BML-265 affects Golgi integrity and transport in human cells but not in rodent cells[1].
CAS Number
183321-62-2
UNSPSC
12352005
Target
EGFR
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
COC1=C(OC)C=C(N=CN=C2NC3=CC=CC(C#C)=C3)C2=C1
Molecular Formula
C18H15N3O2
Molecular Weight
305.33
References & Citations
[1]Boncompain G, et al. BML-265 and Tyrphostin AG1478 Disperse the Golgi Apparatus and Abolish Protein Transport in Human Cells. Front Cell Dev Biol. 2019 Oct 11;7:232.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

N-(3-Ethynylphenyl)-6,7-dimethoxy-4-quinazolinamine

N-(3-ethynylphenyl)-6,7-dimethoxy-4-quinazolinamine is a member of quinazolines.

CAS Number183321-62-2
PubChem CID16045442
IUPAC NameN-(3-ethynylphenyl)-6,7-dimethoxyquinazolin-4-amine
Molecular FormulaC18H15N3O2
Molecular Weight305.3
XLogP3.6
Topological Polar Surface Area56.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count23
Formal Charge0
Complexity435
SMILES
COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OC
InChI
InChI=1S/C18H15N3O2/c1-4-12-6-5-7-13(8-12)21-18-14-9-16(22-2)17(23-3)10-15(14)19-11-20-18/h1,5-11H,2-3H3,(H,19,20,21)
InChIKey
XOTGKYTUNDYTBS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(3-Ethynylphenyl)-6,7-dimethoxy-4-quinazolinamine
CAS: 183321-62-2
CID: 16045442
Formula: C18H15N3O2
MW: 305.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight305.3
XLogP33.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass305.116426730
Monoisotopic Mass305.116426730
Topological Polar Surface Area56.3 Ų
Heavy Atom Count23
Formal Charge0
Complexity435
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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