BML-265

• Description :

  BML-265 is a potent EGFR tyrosine kinase inhibitor. BML-265 disrupts Golgi integrity and abolishes secretory protein transport of diverse cargos. BML-265 affects Golgi integrity and transport in human cells but not in rodent cells[1].

• UNSPSC :

  12352005

• Target :

  EGFR

• Related Pathways :

  JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

• Field of Research :

  Cancer

• Smiles :

  COC1=C(OC)C=C(N=CN=C2NC3=CC=CC(C#C)=C3)C2=C1

• Molecular Formula :

  C18H15N3O2

• Molecular Weight :

  305.33

• References & Citations :

  [1]Boncompain G, et al. BML-265 and Tyrphostin AG1478 Disperse the Golgi Apparatus and Abolish Protein Transport in Human Cells. Front Cell Dev Biol. 2019 Oct 11;7:232.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [183321-62-2]