BML-288

BML-288

• CAS Number: 851681-89-5
• UNSPSC Description: BML-288 (compound Oxindole 1) is a potent PDE2 inhibitor with an IC50 value of 40 nM. BML-288 has the potential for the research of osteoarthritis pain[1].
• Target Antigen: Phosphodiesterase (PDE)
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/bml-288.html
• Smiles: O=C(C1C(N(C)C2=C1C=C(OC=C3)C3=C2)=O)NC4=NN=CS4
• Molecular Weight: 314.32
• References & Citations: [1]Plummer MS, et al. Discovery of potent, selective, bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model, part I: transformation of selective pyrazolodiazepinone phosphodiesterase 4 (PDE4) inhibitors into selective PDE2 inhibitors. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3438-42.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported