JTS-653

• Description:

  JTS-653 is a highly potent and selective transient receptor potential vanilloid 1 (TRPV1) antagonist in vitro and in vivo. JTS-653 attenuates chronic pain refractory to non-steroidal anti-inflammatory agents[1].

• UNSPSC:

  12352005

• Target:

  TRP Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/jts-653.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC[C@@H]1N(C(N=C2)=CC=C2C)C3=CC=CC(C(NC(C=C4)=CN=C4OCC(F)(F)F)=O)=C3OC1

• Molecular Formula:

  C23H21F3N4O4

• Molecular Weight:

  474.43

• References & Citations:

  [1]Yoshihiro Kitagawa, et al. Pharmacological characterization of (3S) -3- (hydroxymethyl) -4- (5-methylpyridin-2-yl) -N-[6- (2,2,2-trifluoroethoxy) pyridin-3-yl]-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxamide (JTS-653), a novel transient receptor potential vanilloid 1 antagonist. J Pharmacol Exp Ther. 2012 Aug;342 (2) :520-8.|[2]Yoshihiro Kitagawa, et al. Orally administered selective TRPV1 antagonist, JTS-653, attenuates chronic pain refractory to non-steroidal anti-inflammatory drugs in rats and mice including post-herpetic pain. J Pharmacol Sci. 2013;122 (2) :128-37.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• Isoform:

  TRPV1

• CAS Number:

  [942614-99-5]