GT-653

• Target:

  Histone Demethylase|||PROTACs

• Related Pathways:

  Chromatin/Epigenetic|||PROTAC

• Bioactivity:

  GT-653 is a PROTAC degrader targeting lysine-specific demethylase 5B (KDM5B) . It induces the degradation of KDM5B via ubiquitin-proteasome pathways, achieving a degradation rate of 68.35% at a concentration of 10 ?M. Additionally, GT-653 upregulates H3K4me3 levels and activates type I interferon signaling pathways in prostate cancer cells 22RV1.

• Molecular Formula:

  C32H27N7O9

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C