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A-actinin (4A12) Mouse mAb

CAT: 0855-EM1261-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-EM1261-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
α-Actinin belongs to the spectrin family of cytoskeletal proteins. α-Actinin is necessary for the attachment of actin filaments to the Z-lines in skeletal muscle cells, and to the dense bodies in smooth muscle cells. The functional protein is an anti-parallel dimer, which cross-links the thin filaments in adjacent sarcomeres, and therefore coordinated contractions between sarcomeres in the horizontal axis.
Description
α-Actinin belongs to the spectrin family of cytoskeletal proteins. α-Actinin is necessary for the attachment of actin filaments to the Z-lines in skeletal muscle cells, and to the dense bodies in smooth muscle cells. The functional protein is an anti-parallel dimer, which cross-links the thin filaments in adjacent sarcomeres, and therefore coordinated contractions between sarcomeres in the horizontal axis.
Product Name Alternative
Actinin 1 smooth muscle antibody, actinin alpha 1 antibody, ACTN 1 antibody, FLJ40884 antibody
UniProt
P12814
Swiss Prot
P12814
Reactivity
Human, Rat, Mouse
Immunogen
Recombinant Protein
Clonality
Monoclonal
Source
Mouse
Applications
IHC
Concentration
1mg/mL
Dilution
IHC 1:100-200
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Molecular Weight
103kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
103kDa
Fragment
IgG1
Subcellular Location
Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane
Other Product Names
Actinin 1 smooth muscle antibody, actinin alpha 1 antibody, ACTN 1 antibody, FLJ40884 antibody
Gene ID (Human)
87

UniProtKB · P12814

Alpha-actinin-1

ACTN1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P12814
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ACTN1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B3V8S3, B4DHH3, B7TY16, Q1HE25, Q9BTN1
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Molecular function

Actin-binding

Coding sequence diversity

Alternative splicing

Ligand

CalciumMetal-binding

Cellular component

Cell junctionCell membraneCell projectionCytoplasmCytoskeletonMembrane

Disease

Disease variant

Domain

Repeat

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