653-47

• Description :

  653-47, a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. 653-47 is also a very weak CREB inhibitor with IC50 of 26.3 μM[1].

• CAS Number :

  [1224678-75-4]

• UNSPSC :

  12352005

• Target :

  Epigenetic Reader Domain

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/653-47.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C1=C(OCCCN)C=C2C=CC=CC2=C1)NC3=CC=C(Cl)C=C3O

• Molecular Formula :

  C20H19ClN2O3

• Molecular Weight :

  370.83

• References & Citations :

  [1]Xie F, et al. Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB) -Mediated Gene Transcription with 666-15. J Med Chem. 2019;62 (24) :11423-11429.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported