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653-47

CAT: 0804-HY-134598Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-134598Size:1 Each
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Description
653-47, a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. 653-47 is also a very weak CREB inhibitor with IC50 of 26.3 μM[1].
CAS Number
1224678-75-4
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/653-47.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(OCCCN)C=C2C=CC=CC2=C1)NC3=CC=C(Cl)C=C3O
Molecular Formula
C20H19ClN2O3
Molecular Weight
370.83
References & Citations
[1]Xie F, et al. Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB) -Mediated Gene Transcription with 666-15. J Med Chem. 2019;62 (24) :11423-11429.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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