Ensaculin (free base)

• Description:

  Ensaculin free base (KA-672) is a NMDA antagonist and have high affinities to serotonergic 5-HT1A and 5-HT7 receptors, adrenergic α1, and dopaminergic D2 and D3 receptors. Ensaculin free base is a memory-enhancing agent. Ensaculin free base has the potential as an antidementia agent acting on various transmitter systems[1].

• Product Name Alternative:

  KA-672; Anseculin

• UNSPSC:

  12352005

• Target:

  5-HT Receptor; Adrenergic Receptor; Dopamine Receptor; iGluR

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ensaculin-free-base.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1OC2=C(C(C)=C1C)C=C(OCCCN3CCN(CC3)C4=C(OC)C=CC=C4)C(OC)=C2

• Molecular Formula:

  C26H32N2O5

• Molecular Weight:

  452.54

• References & Citations:

  [1]Hoerr R, Noeldner M. Ensaculin (KA-672 HCl) : a multitransmitter approach to dementia treatment. CNS Drug Rev. 2002 Summer;8 (2) :143-58.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  5-HT1 Receptor;5-HT7 Receptor

• CAS Number:

  [155773-59-4]