SM-2470

• Description:

  SM-2470 is a potent α1-adrenoceptor antagonist, has sympathetic nerve activity in anesthetized rats[1]. SM-2470 is an antihypertensive agent. SM-2470 exhibits hypocholesterolaemic effect by the inhibition of cholesterol absorption related to the reduction of cholesterol solubilization[2].

• UNSPSC:

  12352005

• Target:

  Adrenergic Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease; Neurological Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/sm-2470.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NC1=NC(N(CC2)CCN2C(C3C(C=C4)CCC4C3)=O)=NC(C=C5OC)=C1C=C5OC.Cl

• Molecular Formula:

  C23H30ClN5O3

• Molecular Weight:

  459.97

• References & Citations:

  [1]M Yoshioka, et al. Effect of SM-2470, a newly synthetized alpha 1-adrenoceptor antagonist, on sympathetic nerve activity in anesthetized rats. Arch Int Pharmacodyn Ther. May-Jun 1988;293:162-74.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  α adrenergic receptor

• CAS Number:

  [99899-45-3]