SM-8849

CAT: 0804-HY-165564Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-165564Size:1 Each
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Description
SM-8849 is a thiazole derivative with anti-arthritis activity. SM-8849 specifically targets and inactivates T cells involved in delayed-type hypersensitivity (DTH) reactions, thereby inhibiting the core immunopathological process of arthritis, but has little effect on the humoral immune process such as antibody production. In a mouse arthritis model induced by Type II Collagen (HY-NP003), SM-8849 significantly alleviated clinical symptoms, reduced bone destruction and joint damage. SM-8849 can be used for the study of autoimmune diseases such as rheumatoid arthritis[1][2].
CAS Number
[113759-19-6]
UNSPSC
12352005
Target
Drug Derivative
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
FC1=C(C2=CC=CC=C2)C=CC(C(C)C3=CSC(NC)=N3)=C1
Molecular Formula
C18H17FN2S
Molecular Weight
312.40
References & Citations
[1]Nagai H, et al. The effect of SM-8849 on experimental arthritis in mice. Pharmacology. 1996 Jun;52 (6) :377-86.|[2]Nishikaku F, Koga Y. Suppression of murine collagen-induced arthritis by treatment with a novel thiazole derivative, SM-8849. Immunopharmacology. 1993 Jan-Feb;25 (1) :65-74.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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