SM-8849

• Description:

  SM-8849 is a thiazole derivative with anti-arthritis activity. SM-8849 specifically targets and inactivates T cells involved in delayed-type hypersensitivity (DTH) reactions, thereby inhibiting the core immunopathological process of arthritis, but has little effect on the humoral immune process such as antibody production. In a mouse arthritis model induced by Type II Collagen (HY-NP003), SM-8849 significantly alleviated clinical symptoms, reduced bone destruction and joint damage. SM-8849 can be used for the study of autoimmune diseases such as rheumatoid arthritis[1][2].

• UNSPSC:

  12352005

• Target:

  Drug Derivative

• Related Pathways:

  Others

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Smiles:

  FC1=C(C2=CC=CC=C2)C=CC(C(C)C3=CSC(NC)=N3)=C1

• Molecular Formula:

  C18H17FN2S

• Molecular Weight:

  312.40

• References & Citations:

  [1]Nagai H, et al. The effect of SM-8849 on experimental arthritis in mice. Pharmacology. 1996 Jun;52 (6) :377-86.|[2]Nishikaku F, Koga Y. Suppression of murine collagen-induced arthritis by treatment with a novel thiazole derivative, SM-8849. Immunopharmacology. 1993 Jan-Feb;25 (1) :65-74.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [113759-19-6]