SM-7368

CAT: 0804-HY-116626-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-116626-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SM-7368 is a potent NF-kB inhibitor that targets downstream of MAPK p38 activation[1]. SM-7368 inhibits TNF-α-induced MMP-9 upregulation. SM-7368 can be used for the research of chemotherapies targeting TNF-α-mediated tumor invasion and metastasis [2].
CAS Number
[380623-76-7]
Product Name Alternative
2'-3'-cyclic GMP-AMP (sodium), 2'-3'-cyclic GMP-AMP
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MMP; NF-κB; p38 MAPK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sm-7368.html
Purity
99.77
Solubility
DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
ClC1=C(C=CC(C(NC2=NC=C(S2)[N+]([O-])=O)=O)=C1)[N+]([O-])=O
Molecular Formula
C10H5ClN4O5S
Molecular Weight
328.69
Precautions
H302, H315, H319, H335
References & Citations
[1]Sabine Kuntz, et al. Carbonyl compounds methylglyoxal and glyoxal affect interleukin-8 secretion in intestinal cells by superoxide anion generation and activation of MAPK p38. Mol Nutr Food Res. 2010 Oct;54 (10) :1458-67.|[2]Ha Young Lee, et al. A small compound that inhibits tumor necrosis factor-alpha-induced matrix metalloproteinase-9 upregulation. Biochem Biophys Res Commun. 2005 Oct 21;336 (2) :716-22.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MMP-9; NF-κB; p38 MAPK

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