SM-7368

• Description :

  SM-7368 is a potent NF-kB inhibitor that targets downstream of MAPK p38 activation[1]. SM-7368 inhibits TNF-α-induced MMP-9 upregulation. SM-7368 can be used for the research of chemotherapies targeting TNF-α-mediated tumor invasion and metastasis [2].

• Product Name Alternative :

  2'-3'-cyclic GMP-AMP (sodium), 2'-3'-cyclic GMP-AMP

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  MMP; NF-κB; p38 MAPK

• Type :

  Reference compound

• Related Pathways :

  MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/sm-7368.html

• Purity :

  99.77

• Solubility :

  DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  ClC1=C(C=CC(C(NC2=NC=C(S2)[N+]([O-])=O)=O)=C1)[N+]([O-])=O

• Molecular Formula :

  C10H5ClN4O5S

• Molecular Weight :

  328.69

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Sabine Kuntz, et al. Carbonyl compounds methylglyoxal and glyoxal affect interleukin-8 secretion in intestinal cells by superoxide anion generation and activation of MAPK p38. Mol Nutr Food Res. 2010 Oct;54 (10) :1458-67.|[2]Ha Young Lee, et al. A small compound that inhibits tumor necrosis factor-alpha-induced matrix metalloproteinase-9 upregulation. Biochem Biophys Res Commun. 2005 Oct 21;336 (2) :716-22.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MMP-9; NF-κB; p38 MAPK

• CAS Number :

  [380623-76-7]