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YM-1 (tosylate)

CAT: 0804-HY-18406Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-18406Size:1 Each
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Description
YM-1 tosylate is a stable MKT-077 analog and an orally active Hsp70 inhibitor. YM-1 tosylate induces cell death of HeLa cells and up-regulates the level of p53 and p21 proteins[1][2].
CAS Number
1427450-47-2
UNSPSC
12352005
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hsp70-in-4.html
Solubility
10 mM in DMSO
Smiles
CN(C1=CC=CC=C1S/2)C2=C3C(N(CC)/C(S\3)=C/C4=[N+](C)C=CC=C4)=O.[O-]S(=O)(C5=CC=C(C)C=C5)=O
Molecular Formula
C27H27N3O4S3
Molecular Weight
553.72
References & Citations
[1]Miyata Y, et al. Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels. ACS Chem Neurosci. 2013 Jun 19;4 (6) :930-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP70

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