YM-1

CAT: 0804-HY-18399-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-18399-01Size:5 mg
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Description
YM-1 is a stable MKT-077 (HY-15096) analog and an orally active Hsp70 inhibitor. YM-1 induces cell death of HeLa cells and up-regulates the level of p53 and p21 proteins[1][2].
CAS Number
[409086-68-6]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
HSP; NO Synthase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ym-1.html
Purity
99.25
Solubility
DMSO : 30 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 50 mg/mL (ultrasonic)
Smiles
CN(C1=CC=CC=C1S/2)C2=C3C(N(CC)/C(S\3)=C/C4=[N+](C)C=CC=C4)=O.[Cl-]
Molecular Formula
C20H20ClN3OS2
Molecular Weight
417.98
Precautions
H302, H315, H319
References & Citations
[1]Wang AM, et al. Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation. Nat Chem Biol. 2013 Feb;9 (2) :112-8.|[2]Khondoker Md Zulfiker Rahman, et al. Effect of an Inhibitor of HSP70, YM-1, on Hikeshi Knockout Cells. Thermal Medicine. 2017, 33 (4) :129-134.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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