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MK-7145

CAT: 0804-HY-18277Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-18277Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MK-7145 is a ROMK inhibitor, with an IC50 of 0.045 μM.
CAS Number
[1255204-84-2]
UNSPSC
12352005
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/MK-7145.html
Solubility
10 mM in DMSO
Smiles
O[C@H](C1=C(C)C2=C(C(OC2)=O)C=C1)CN3CCN(C[C@@H](C4=C(C)C5=C(C(OC5)=O)C=C4)O)CC3
Molecular Formula
C26H30N2O6
Molecular Weight
466.53
References & Citations
[1]Tang H, et al. Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure. ACS Med Chem Lett. 2016 May 12;7 (7) :697-701.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1

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MBS3845463-01MK-7145
A21030-10MK-7145 10mg
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