MK-7145

• UNSPSC Description:

  MK-7145 is a ROMK inhibitor, with an IC50 of 0.045 μM.

• Target Antigen:

  Potassium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/MK-7145.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O[C@H](C1=C(C)C2=C(C(OC2)=O)C=C1)CN3CCN(C[C@@H](C4=C(C)C5=C(C(OC5)=O)C=C4)O)CC3

• Molecular Weight:

  466.53

• References & Citations:

  [1]Tang H, et al. Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure. ACS Med Chem Lett. 2016 May 12;7(7):697-701.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Phase 1

• CAS Number:

  1255204-84-2