MK-7145

• Description:

  MK-7145 is a ROMK inhibitor, with an IC50 of 0.045 μM.

• UNSPSC:

  12352005

• Target:

  Potassium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/MK-7145.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O[C@H] (C1=C (C) C2=C (C (OC2) =O) C=C1) CN3CCN (C[C@@H] (C4=C (C) C5=C (C (OC5) =O) C=C4) O) CC3

• Molecular Formula:

  C26H30N2O6

• Molecular Weight:

  466.53

• References & Citations:

  [1]Tang H, et al. Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure. ACS Med Chem Lett. 2016 May 12;7 (7) :697-701.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• CAS Number:

  1255204-84-2