MK-7145

MK-7145

• CAS Number: 1255204-84-2
• UNSPSC Description: MK-7145 is a ROMK inhibitor, with an IC50 of 0.045 μM.
• Target Antigen: Potassium Channel
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Applications: Neuroscience-Neuromodulation
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/MK-7145.html
• Solubility: 10 mM in DMSO
• Smiles: O[C@H](C1=C(C)C2=C(C(OC2)=O)C=C1)CN3CCN(C[C@@H](C4=C(C)C5=C(C(OC5)=O)C=C4)O)CC3
• Molecular Weight: 466.53
• References & Citations: [1]Tang H, et al. Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure. ACS Med Chem Lett. 2016 May 12;7(7):697-701.
• Shipping Conditions: Room temperature
• Clinical Information: Phase 1