MK-7145

• Description :

  MK-7145 is a ROMK inhibitor, with an IC50 of 0.045 μM.

• UNSPSC :

  12352005

• Target :

  Potassium Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/MK-7145.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O[C@H](C1=C(C)C2=C(C(OC2)=O)C=C1)CN3CCN(C[C@@H](C4=C(C)C5=C(C(OC5)=O)C=C4)O)CC3

• Molecular Formula :

  C26H30N2O6

• Molecular Weight :

  466.53

• References & Citations :

  [1]Tang H, et al. Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure. ACS Med Chem Lett. 2016 May 12;7 (7) :697-701.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• CAS Number :

  [1255204-84-2]