AChE-IN-52

• Description :

  AChE-IN-52 (compound A6) is an acetylcholinesterase (AChE) inhibitor. AChE-IN-52 shows antitumor efficacy, especially against breast cancer MCF-7 cells. AChE-IN-52 significantly disrupts the amino acid metabolism and inhibits migration of MCF-7. AChE-IN-52 plays anticancer role by regulating Best1 and HIST1H2BJ[1].

• UNSPSC :

  12352005

• Target :

  Cholinesterase (ChE)

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ache-in-52.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C1=CSC(C2=CC=C(OCC3=CC=CC=C3)C=C2)=N1)NCCN4CCCCC4

• Molecular Formula :

  C24H27N3O2S

• Molecular Weight :

  421.56

• References & Citations :

  [1]Shi X, et al. Identification of a 2-phenylthiazole derivative acetylcholinesterase modulator with in vitro antitumor activity in breast cancer cells. Chem Biol Drug Des. 2023 Nov 27:e14402.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  AChE

• CAS Number :

  [2214210-63-4]