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MAT2A-IN-14

CAT: 0804-HY-162135Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162135Size:1 Each
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Description
MAT2A-IN-14 (compound H3) is a MAT2A inhibitor, and generates reactive oxygen species after sonication to specifically degrade cellular MAT2A via rapid oxidative reactions. Combination of MAT2A-IN-14 and sonication induces 87% MAT2A depletion in human colon cancer cell[1].
UNSPSC
12352005
Target
Methionine Adenosyltransferase (MAT) ; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mat2a-in-14.html
Solubility
10 mM in DMSO
Smiles
O=C1C(C2=CC=C(C3=C2)OCC4N3CCC4)=CC(C=NC(OCC)=N5)=C5N1C6=CC=C(C=C6)OC(F)F
Molecular Formula
C27H24F2N4O4
Molecular Weight
506.50
References & Citations
[1]He H, et al. Identification of a Sonically Activated Degrader of Methionine Adenosyltransferase 2A by an in Silico Approach Assisted with the Hole-Electron Analysis. J Med Chem. 2024;67 (1) :543-554.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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