MAT2A-IN-14

• UNSPSC Description:

  MAT2A-IN-14 (compound H3) is a MAT2A inhibitor, and generates reactive oxygen species after sonication to specifically degrade cellular MAT2A via rapid oxidative reactions. Combination of MAT2A-IN-14 and sonication induces 87% MAT2A depletion in human colon cancer cell[1].

• Target Antigen:

  Methionine Adenosyltransferase (MAT); Reactive Oxygen Species

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/mat2a-in-14.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1C(C2=CC=C(C3=C2)OCC4N3CCC4)=CC(C=NC(OCC)=N5)=C5N1C6=CC=C(C=C6)OC(F)F

• Molecular Weight:

  506.50

• References & Citations:

  [1]He H, et al. Identification of a Sonically Activated Degrader of Methionine Adenosyltransferase 2A by an in Silico Approach Assisted with the Hole-Electron Analysis. J Med Chem. 2024;67(1):543-554.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported