MAT2A-IN-14
CAT:
804-HY-162135
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No

MAT2A-IN-14
- UNSPSC Description: MAT2A-IN-14 (compound H3) is a MAT2A inhibitor, and generates reactive oxygen species after sonication to specifically degrade cellular MAT2A via rapid oxidative reactions. Combination of MAT2A-IN-14 and sonication induces 87% MAT2A depletion in human colon cancer cell[1].
- Target Antigen: Methionine Adenosyltransferase (MAT); Reactive Oxygen Species
- Type: Reference compound
- Related Pathways: Epigenetics;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/mat2a-in-14.html
- Solubility: 10 mM in DMSO
- Smiles: O=C1C(C2=CC=C(C3=C2)OCC4N3CCC4)=CC(C=NC(OCC)=N5)=C5N1C6=CC=C(C=C6)OC(F)F
- Molecular Weight: 506.50
- References & Citations: [1]He H, et al. Identification of a Sonically Activated Degrader of Methionine Adenosyltransferase 2A by an in Silico Approach Assisted with the Hole-Electron Analysis. J Med Chem. 2024;67(1):543-554.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported