PROTAC GPX4 degrader-2

PROTAC GPX4 degrader-2

• UNSPSC Description: PROTAC GPX4 degrader-2 (compound 18a) is a proteolysis targeting chimeras (PROTACs) that can degrade glutathione peroxidase 4 (GPX4), with the DC50, 48h value of 1.68 μM. PROTAC GPX4 degrader-2 induces the accumulation of lipid peroxides and mitochondrial depolarization, subsequently triggering ferroptosis. PROTAC GPX4 degrader-2 has anti-proliferative effect[1].
• Target Antigen: Ferroptosis; Glutathione Peroxidase; PROTACs
• Type: Reference compound
• Related Pathways: Apoptosis;Metabolic Enzyme/Protease;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/protac-gpx4-degrader-2.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(NCC1=CN(CCCCCCCC(N[C@@H]([C@H](O)C(N[C@@H](CC(C)C)C(OC)=O)=O)CC2=CC=CC=C2)=O)N=N1)C(C=C3)=CC=C3[C@H](N(C(CCl)=O)[C@@H](C(OC)=O)C4)C5=C4C6=CC=CC=C6N5
• Molecular Weight: 953.52
• References & Citations: [1]Haoze Song, et al. A potent GPX4 degrader to induce ferroptosis in HT1080 cells. Eur J Med Chem. 2023 Dec 31:265:116110.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported