PROTAC GPX4 degrader-1
CAT:
804-HY-149236-02
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
PROTAC GPX4 degrader-1
- CAS Number: 2916433-81-1
- UNSPSC Description: PROTAC GPX4 degrader-1 (DC-2) is a PROTAC-based GPX4 degrader, with a DC50 of 0.03 μM in HT1080 cells[1].
- Target Antigen: Ferroptosis; Glutathione Peroxidase; PROTACs
- Type: Reference compound
- Related Pathways: Apoptosis;Metabolic Enzyme/Protease;PROTAC
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/protac-gpx4-degrader-1.html
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: O=C(N1CCN(C(C2=CC=C(C=C2)OCC(N3CCC(CC3)CN4CCN(CCCNC5=CC=CC(C(N6C7C(NC(CC7)=O)=O)=O)=C5C6=O)CC4)=O)C8=CC=C(C=C8)Cl)CC1)C9=NOC(C)=C9[N+]([O-])=O
- Molecular Weight: 993.50
- References & Citations: [1]Han Wang, et al. Discovery of ML210-Based glutathione peroxidase 4 (GPX4) degrader inducing ferroptosis of human cancer cells. Eur J Med Chem. 2023 Jun 5;254:115343.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported