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AMPK activator 14

CAT: 0804-HY-162042Size: 1 EachDry Ice: NoHazardous: No
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Description
AMPK activator 14 (compound 32) is an orally active AMPK activator. AMPK activator 14 decreases fasted glucose and insulin levels in a db/db mouse model of Type II diabetes[1].
CAS Number
1356632-18-2
UNSPSC
12352005
Target
AMPK
Type
Reference compound
Related Pathways
Epigenetics; PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ampk-activator-14.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C=C1)C(C2CCN(CC2)C(C3=NC=C(C=C3)C(N[C@H]4CCN(CC5=CC=C(C=C5)C#N)C[C@@H]4F)=O)=O)=O
Molecular Formula
C33H34FN5O4
Molecular Weight
583.65
References & Citations
[1]Shaw SJ, et al. Optimization of Pharmacokinetic and In Vitro Safety Profile of a Series of Pyridine Diamide Indirect AMPK Activators. J Med Chem. 2023;66 (24) :17086-17104.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

AMPK activator 14
CAS Number1356632-18-2
PubChem CID56652377
IUPAC NameN-[(3S,4S)-1-[(4-cyanophenyl)methyl]-3-fluoropiperidin-4-yl]-6-[4-(4-methoxybenzoyl)piperidine-1-carbonyl]pyridine-3-carboxamide
Molecular FormulaC33H34FN5O4
Molecular Weight583.7
XLogP3.6
Topological Polar Surface Area116
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count8
Heavy Atom Count43
Formal Charge0
Complexity1010
SMILES
COC1=CC=C(C=C1)C(=O)C2CCN(CC2)C(=O)C3=NC=C(C=C3)C(=O)N[C@H]4CCN(C[C@@H]4F)CC5=CC=C(C=C5)C#N
InChI
InChI=1S/C33H34FN5O4/c1-43-27-9-6-24(7-10-27)31(40)25-12-16-39(17-13-25)33(42)30-11-8-26(19-36-30)32(41)37-29-14-15-38(21-28(29)34)20-23-4-2-22(18-35)3-5-23/h2-11,19,25,28-29H,12-17,20-21H2,1H3,(H,37,41)/t28-,29-/m0/s1
InChIKey
LEUSDRGCPVXECX-VMPREFPWSA-N
Chemical Structure
2D Structure
2D structure of AMPK activator 14
CAS: 1356632-18-2
CID: 56652377
Formula: C33H34FN5O4
MW: 583.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight583.7
XLogP33.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count8
Exact Mass583.25948274
Monoisotopic Mass583.25948274
Topological Polar Surface Area116 Ų
Heavy Atom Count43
Formal Charge0
Complexity1010
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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