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MAT2A-IN-24

CAT: 0804-HY-173281Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-173281Size:1 Each
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Description
MAT2A-IN-24 (Compound 9) is an inhibitor of methionine adenosyltransferase 2a (MAT2a) . The IC50 value for the inhibition of MAT2a is 20 nM, and the IC50 value for the antiproliferative activity against HAP1MTAP–/– cells is 10 nM. MAT2A-IN-24 can be used in the research field of tumor diseases associated with MTAP deficiency[1].
CAS Number
3031093-57-6
UNSPSC
12352005
Target
Methionine Adenosyltransferase (MAT)
Related Pathways
Epigenetics; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
CN(C)C(C1=C(N2C3=CC=CC(N4CCC(CN5C(C=C(Cl)C=C6)=C6C(N(C)C)=NC5=O)CC4)=C3)C=C(Cl)C=C1)=NC2=O
Molecular Formula
C32H33Cl2N7O2
Molecular Weight
618.56
References & Citations
[1]Zhou Y, et al. Structure-Based Discovery of a Series of Novel MAT2a Inhibitors. ACS Med Chem Lett. 2025 Mar 15;16 (4) :646-650.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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