MAT2A-IN-24

• Description:

  MAT2A-IN-24 (Compound 9) is an inhibitor of methionine adenosyltransferase 2a (MAT2a) . The IC50 value for the inhibition of MAT2a is 20 nM, and the IC50 value for the antiproliferative activity against HAP1MTAP–/– cells is 10 nM. MAT2A-IN-24 can be used in the research field of tumor diseases associated with MTAP deficiency[1].

• UNSPSC:

  12352005

• Target:

  Methionine Adenosyltransferase (MAT)

• Related Pathways:

  Epigenetics; Metabolic Enzyme/Protease

• Field of Research:

  Cancer

• Smiles:

  CN(C)C(C1=C(N2C3=CC=CC(N4CCC(CN5C(C=C(Cl)C=C6)=C6C(N(C)C)=NC5=O)CC4)=C3)C=C(Cl)C=C1)=NC2=O

• Molecular Formula:

  C32H33Cl2N7O2

• Molecular Weight:

  618.56

• References & Citations:

  [1]Zhou Y, et al. Structure-Based Discovery of a Series of Novel MAT2a Inhibitors. ACS Med Chem Lett. 2025 Mar 15;16 (4) :646-650.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  3031093-57-6