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KIO-301 (chloride)

CAT: 0804-HY-161092Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161092Size:1 Each
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Description
KIO-301 chloride is an azobenzene photoswitch compound that can block voltage-gated ion channels, including hyperpolarisation-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium channels during exposure to visible light[1].
CAS Number
1643463-59-5
UNSPSC
12352005
Target
HCN Channel; Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/kio-301-chloride.html
Solubility
10 mM in DMSO
Smiles
O=C(C[N+](CC)(CC)CC)NC(C=C1)=CC=C1/N=N/C2=CC=C(N(CC3=CC=CC=C3)CC)C=C2.[Cl-]
Molecular Formula
C29H38ClN5O
Molecular Weight
508.10
References & Citations
[1]Eric Daniels, et al. An Intravitreal 'Photoswitch' Molecule (KIO-301) for Reanimation in Retinitis Pigmentosa: a first-in-human trial. Investigative Ophthalmology & Visual Science June 2023, Vol.64, 5444.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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