IMB-301

• Description:

  IMB-301 is a specific HIV-1 replication inhibitor that binds to hA3G (human APOBEC3G), interrupts the hA3G-Vif interaction and inhibits Vif-mediated degradation of hA3G. IMB-301 inhibits the replication of HIV-1 in H9 cells (IC50=8.63 uM) . Human APOBEC3G is a restriction factor that inhibits human immunodeficiency 1 virus (HIV-1) replication[1].

• UNSPSC:

  12352005

• Target:

  HIV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/imb-301.html

• Purity:

  99.08

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  FC1=CC=C(OCCC(C2=CC=C(Cl)C=C2Cl)CN3C=CN=C3)C=C1

• Molecular Formula:

  C19H17Cl2FN2O

• Molecular Weight:

  379.26

• References & Citations:

  [1]Ma L, et al. Identification of small molecule compounds targeting the interaction of HIV-1 Vif and human APOBEC3G by virtual screening and biological evaluation. Sci Rep. 2018;8 (1) :8067. Published 2018 May 23.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  HIV-1

• CAS Number:

  [64009-84-3]