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TIK-301

CAT: 0804-HY-106136Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-106136Size:1 Each
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Description
TIK-301 (PD-6735) is a chlorinated melatonin derivative and a potent, high-affinity and orally active melatonin MT1 and MT2 receptors agonist with Kis of 0.081 nM and 0.042 nM, respectively. TIK-301 is also a 5-HT2B/5-HT2C receptors antagonist with antidepressant action. TIK-301 has the potential for sleep disorders and other circadian rhythm disorders treatment[1][2][3].
CAS Number
118702-11-7
Product Name Alternative
PD-6735; LY-156735
UNSPSC
12352005
Target
5-HT Receptor; Melatonin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tik-301.html
Solubility
10 mM in DMSO
Smiles
CC(NC[C@@H](C1=CNC2=C1C=C(OC)C(Cl)=C2)C)=O
Molecular Formula
C14H17ClN2O2
Molecular Weight
280.75
References & Citations
[1]Paulis L, et al. Cardiovascular effects of melatonin receptor agonists. Expert Opin Investig Drugs. 2012 Nov;21 (11) :1661-78.|[2]Rivara S, et al. Melatonin receptor agonists: SAR and applications to the treatment of sleep-wake disorders. Curr Top Med Chem. 2008;8 (11) :954-68.|[3] Carocci A, et al. Melatonergic drugs in development. Clin Pharmacol. 2014 Sep 18;6:127-37.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
5-HT2 Receptor; MT1; MT2; α-1 microglobulin

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