TIK-301

• Description:

  TIK-301 (PD-6735) is a chlorinated melatonin derivative and a potent, high-affinity and orally active melatonin MT1 and MT2 receptors agonist with Kis of 0.081 nM and 0.042 nM, respectively. TIK-301 is also a 5-HT2B/5-HT2C receptors antagonist with antidepressant action. TIK-301 has the potential for sleep disorders and other circadian rhythm disorders treatment[1][2][3].

• Product Name Alternative:

  PD-6735; LY-156735

• UNSPSC:

  12352005

• Target:

  5-HT Receptor; Melatonin Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/tik-301.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(NC[C@@H](C1=CNC2=C1C=C(OC)C(Cl)=C2)C)=O

• Molecular Formula:

  C14H17ClN2O2

• Molecular Weight:

  280.75

• References & Citations:

  [1]Paulis L, et al. Cardiovascular effects of melatonin receptor agonists. Expert Opin Investig Drugs. 2012 Nov;21 (11) :1661-78.|[2]Rivara S, et al. Melatonin receptor agonists: SAR and applications to the treatment of sleep-wake disorders. Curr Top Med Chem. 2008;8 (11) :954-68.|[3] Carocci A, et al. Melatonergic drugs in development. Clin Pharmacol. 2014 Sep 18;6:127-37.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• Isoform:

  5-HT2 Receptor; MT1; MT2; α-1 microglobulin

• CAS Number:

  [118702-11-7]