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RU-301

CAT: 0804-HY-119039-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-119039-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RU-301 is a pan TAM inhibitor that blocks Gas6-induced TAM activation and tumorigenicity. RU-301 significantly reduces nonalcoholic steatohepatitis (NASH) fibrosis, along with attenuates ERK activation and TGFβ1 expression. RU-301 can be used in studies of cancer and nonalcoholic steatohepatitis[1][2].
CAS Number
[1110873-99-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
TAM Receptor
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ru-301.html
Purity
99.75
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NCCNC1=CC=C(C(F)(F)F)C=C1[N+]([O-])=O)C2=CC=CC=C2SCC3=CC(C)=NO3
Molecular Formula
C21H19F3N4O4S
Molecular Weight
480.46
Precautions
H302, H315, H319, H335
References & Citations
[1]Kimani SG, et al. Small molecule inhibitors block Gas6-inducible TAM activation and tumorigenicity. Sci Rep. 2017 Mar 8;7:43908.|[2]Cai B, et al. Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis. Cell Metab. 2020 Feb 4;31 (2) :406-421.e7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

CatalogName
C06980-01RU-301
A19156-100RU-301 100mg
A19156-5RU-301 5mg
A19156-10RU-301 10mg
A19156-1RU-301 1mg
A19156-25RU-301 25mg
A19156-50RU-301 50mg
A19156-10mM-DRU-301 10mM * 1mL in DMSO
MBS6026838-01Mifepristone (RU-486, RU-38486, Mifegyne,)
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