JKC 301

CAT: 0804-HY-P4201Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-P4201Size:1 Each
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Description
JKC 301 is a selective Endothelin A receptor antagonist. JKC 301 attenuates the pressor effects of nicotine in rats. JKC 301 can be used to study cardiovascular disease caused by smoking[1][2].
CAS Number
[136553-96-3]
UNSPSC
12352209
Target
Vasopressin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/jkc-301.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](C(N(CCC1)[C@]1([H])C2=O)=O)CC(O)=O)[C@H](NC([C@@H](NC([C@@](N2)([H])[C@H](C)CC)=O)CC(C)C)=O)CC3=CNC4=CC=CC=C34
Molecular Formula
C32H44N6O7
Molecular Weight
624.73
References & Citations
[1]Tanus-Santos JE, Sampaio RC, Hyslop S, Franchini KG, Moreno H Jr. Endothelin ET (A) receptor antagonism attenuates the pressor effects of nicotine in rats. Eur J Pharmacol. 2000 May 12;396 (1) :33-7. |[2]Ngoka LC, et al. Location of alkali metal binding sites in endothelin A selective receptor antagonists, cyclo (D-Trp-D-Asp-Pro-D-Val-Leu) and cyclo (D-Trp-D-Asp-Pro-D-Ile-Leu), from multistep collisionally activated decompositions. J Mass Spectrom. 2000 Feb;35 (2) :265-76.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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