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SHP2-IN-24

CAT: 0804-HY-157535Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-157535Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SHP2-IN-24 (compound 111675) is a potent SHP2 inhibitor with an IC50 value of 0.878 µM and a Ki value of 0.118 µM[1].
UNSPSC
12352005
Target
SHP2
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/shp2-in-24.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C=C1C2=NN=C(SCC(N[C@@H](C(OC)=O)CC3=CNC4=CC=CC=C43)=O)N2)Cl
Molecular Formula
C23H22ClN5O4S
Molecular Weight
499.97
References & Citations
[1]Mitra R, et al. Identification of new small molecule allosteric SHP2 inhibitor through pharmacophore-based virtual screening, molecular docking, molecular dynamics simulation studies, synthesis and in vitro evaluation. J Biomol Struct Dyn. 2023 Dec 14:1-20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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