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EGFR-TK-IN-1

CAT: 0804-HY-157526Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-157526Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EGFR-TK-IN-1 (compound 7o) is a potent mutant EGFR inhibitor with IC50 of 8.5 nM an 9.3 nM against EGFRL858R/T790M and EGFRDel19.EGFR-TK-IN-1 showes strong antiproliferative effects against EGFR mutant-driven non-small cell lung cancer (NSCLC) cells and induces cell apoptosis[1].
UNSPSC
12352005
Target
Apoptosis; EGFR
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-tk-in-1.html
Solubility
10 mM in DMSO
Smiles
C=CC(NC1=CC=CC(N2C(COC3=CC=CC(OC)=C3)=CC4=CN=C(NC5=CC=C(N6CCC(N(C)C)CC6)C=C5)N=C42)=C1)=O
Molecular Formula
C36H39N7O3
Molecular Weight
617.74
References & Citations
[1]Wang C, et al. Design, synthesis and biological evaluation of potent epidermal growth factor receptor tyrosine kinase (EGFR-TK) inhibitors against resistance mutation for lung cancer treatment. Bioorg Chem. 2023 Dec 6;143:107004.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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