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AChE/Aβ-IN-3

CAT: 0804-HY-157440Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-157440Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AChE/Aβ-IN-3 (compound AM5) is a dual inhibitor of AChE and Amyloid-β aggregation with IC50 values of 1.29 and 4.93 μM, respectively. AChE/Aβ-IN-3 has antioxidant properties that scavenge ROS and restore their normal levels. AChE/Aβ-IN-3 can be used in the study of neurological diseases, such as Alzheimer's disease[1].
UNSPSC
12352005
Target
Amyloid-β; Cholinesterase (ChE) ; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-aβ-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=CC(C(F)(F)F)=C1)CN2CCN(C3=CC(NC4=C3C=CC=C4)=O)CC2
Molecular Formula
C22H21F3N4O2
Molecular Weight
430.42
References & Citations
[1]Manzoor S, et al. Discovery of Quinolinone Hybrids as Dual Inhibitors of Acetylcholinesterase and Aβ Aggregation for Alzheimer's Disease Therapy. ACS Chem Neurosci. 2023 Dec 27.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE

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