AChE/Aβ-IN-3

AChE/Aβ-IN-3

• UNSPSC Description: AChE/Aβ-IN-3 (compound AM5) is a dual inhibitor of AChE and Amyloid-β aggregation with IC50 values of 1.29 and 4.93 μM, respectively. AChE/Aβ-IN-3 has antioxidant properties that scavenge ROS and restore their normal levels. AChE/Aβ-IN-3 can be used in the study of neurological diseases, such as Alzheimer's disease[1].
• Target Antigen: Amyloid-β; Cholinesterase (ChE); Reactive Oxygen Species
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease;Neuronal Signaling;NF-κB
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/ache-aβ-in-3.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(NC1=CC=CC(C(F)(F)F)=C1)CN2CCN(C3=CC(NC4=C3C=CC=C4)=O)CC2
• Molecular Weight: 430.42
• References & Citations: [1]Manzoor S, et al. Discovery of Quinolinone Hybrids as Dual Inhibitors of Acetylcholinesterase and Aβ Aggregation for Alzheimer's Disease Therapy. ACS Chem Neurosci. 2023 Dec 27.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported