AChE/GSK-3β-IN-1

AChE/GSK-3β-IN-1

• CAS Number: 2412364-73-7
• UNSPSC Description: AChE/GSK-3β-IN-1 (compound GT15) is a potent, dual AChE/GSK-3β inhibitor with IC50 values of 1.2, 149.8 and 22.4 nM for hAChE , hBChE and hGSK-3β, respectively. AChE/GSK-3β-IN-1 penetrates the blood-brain barrier (BBB). AChE/GSK-3β-IN-1 has high kinase selectivity profiles for the CMGC kinase family. AChE/GSK-3β-IN-1 occupies the ATP binding site of DYRK1A. AChE/GSK-3β-IN-1 inhibits ROS expression and reduces oxidative stress. AChE/GSK-3β-IN-1 can be used for Alzheimer’s disease research[1].
• Target Antigen: Cholinesterase (ChE); GSK-3; Microtubule/Tubulin; ROS Kinase
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Cytoskeleton;Neuronal Signaling;PI3K/Akt/mTOR;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/ache-gsk-3β-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: CNC(C(S1)=C(N=C1C2=CC(NC(CNCCNC3=C4CCCCC4=NC5=CC=CC=C35)=O)=NC=C2)OCC6CC6)=O
• Molecular Weight: 585.72
• References & Citations: [1]Jiang X, et, al. Rational design and biological evaluation of a new class of thiazolopyridyl tetrahydroacridines as cholinesterase and GSK-3 dual inhibitors for Alzheimer's disease. Eur J Med Chem. 2020 Dec 1;207:112751.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported