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SEH/AChE-IN-3

CAT: 0804-HY-145833Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-145833Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SEH/AChE-IN-3 (compound (−) -15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC50 values of 0.4 nM (hsEH), 1.94 nM (hAChE), 615 (hBChE, human butyrylcholinesterase), 4.3 nM (msEH), and 2.61 nM (mAChE), respectively[1].
CAS Number
2490589-11-0
UNSPSC
12352005
Target
Cholinesterase (ChE) ; Epoxide Hydrolase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/seh-ache-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(OC(F)(F)F)C=C1)NC2CCN(C(CCCCNC3=C([C@]4([H])CC(C)=C[C@](C4)([H])C5)C5=NC6=CC(Cl)=CC=C36)=O)CC2
Molecular Formula
C35H39ClF3N5O3
Molecular Weight
670.16
References & Citations
[1]Codony S, et al. Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease. J Med Chem. 2022 Mar 24;65 (6) :4909-4925.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE

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