sEH/AChE-IN-3

• UNSPSC Description:

  sEH/AChE-IN-3 (compound (−)-15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC50 values of 0.4 nM (hsEH), 1.94 nM (hAChE), 615 (hBChE, human butyrylcholinesterase), 4.3 nM (msEH), and 2.61 nM (mAChE), respectively[1].

• Target Antigen:

  Cholinesterase (ChE); Epoxide Hydrolase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease;Neuronal Signaling

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/seh-ache-in-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NC1=CC=C(OC(F)(F)F)C=C1)NC2CCN(C(CCCCNC3=C([C@]4([H])CC(C)=C[C@](C4)([H])C5)C5=NC6=CC(Cl)=CC=C36)=O)CC2

• Molecular Weight:

  670.16

• References & Citations:

  [1]Codony S, et al. Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease. J Med Chem. 2022 Mar 24;65(6):4909-4925.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2490589-11-0