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CDK-IN-13

CAT: 0804-HY-157297Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-157297Size:1 Each
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Description
CDK-IN-13 (compound 32E) is a potent and selective inhibitor of CDK12/cyclinK with an IC50 of 3 nM. CDK-IN-13 inhibits the growth of the HER2-positive breast cancer cell lines[1].
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk-in-13.html
Solubility
10 mM in DMSO
Smiles
CCN1C=NC2=C(N=C(N=C21)N3CCOC[C@H]3CCO)NCC4=CN=C(C=C4)C5=COC=C5
Molecular Formula
C23H27N7O3
Molecular Weight
449.51
References & Citations
[1]Kuchukulla RR, et al. Identification of a novel potent CDK inhibitor degrading cyclinK with a superb activity to reverse trastuzumab-resistance in HER2-positive breast cancer in vivo. Eur J Med Chem. 2024 Jan 15;264:116014.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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