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CDK-IN-14

CAT: 0804-HY-168067Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168067Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CDK-IN-14 (B34) is a CDK2 inhibitor (IC50=0.097 μM) with anti-hepatocellular carcinoma activity. CDK-IN-14 blocks the cell cycle of HepG-2 cancer cells through a caspase-mediated mechanism and induces apoptosis[1].
UNSPSC
12352005
Target
Apoptosis; Caspase; CDK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk-in-14-1.html
Smiles
COC1=C(OC)C=C(N=C(NC2=CC=C(OCC3=CC(F)=CC=C3)C(Cl)=C2)N=C4NCC5=CC=CC=C5)C4=C1
Molecular Formula
C30H26ClFN4O3
Molecular Weight
545.00
References & Citations
[1]Venkatesan G, et al. Design, synthesis, molecular docking, and evaluation of sulfonyl quinazoline analogues as promising liver cancer drugs[J]. Bioorganic Chemistry, 2024: 107777.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK2

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