TrkA-IN-6

CAT: 0804-HY-157168Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-157168Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TrkA-IN-6 (compound R48) is a hydrazone-like, selective inhibitor of tropomyosin kinase type A receptor kinase (TrkA) . TrkA-IN-6 exhibited a higher cytotoxic effect on U87 GBM cells than Temozolomide (HY-17364), with an IC50 of 68.99 μM[1].
UNSPSC
12352005
Target
Trk Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/trka-in-6.html
Solubility
10 mM in DMSO
Smiles
CC(/C(C(C1=CC=CC=C1)=O)=N\NC2=CC=C([N+]([O-])=O)C=C2O)=O
Molecular Formula
C16H13N3O5
Molecular Weight
327.29
References & Citations
[1]Murugesan A et al. Design, synthesis and anticancer evaluation of novel arylhydrazones of active methylene compounds. Int J Biol Macromol. 2023 Nov 10;254 (Pt 3) :127909.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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